5-Amino-1MQ
5-Amino-1-methylquinolinium (5-Amino-1MQ)
What is 5-Amino-1MQ?
5-Amino-1MQ: Small-molecule (not a peptide) membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme in fat tissue that consumes NAD+ precursors. The sources cited here most often discuss it for: Fat loss, mice; Aged muscle regeneration, mice; Metabolic health, mice. Evidence label: Preclinical.
- Type
- Not a peptide
- Family
- Weight & Metabolic
- Evidence label
- Preclinical (2 of 5)
- Regulatory status
- A March 2026 report on FDA warning letters says FDA inspectors found that compounder GenoGenix made 5-Amino-1MQ, which is ineligible for the section 503B compounding exemptions.
- Goals discussed
- Fat Loss & Metabolism, Muscle & Tone, Healing & Recovery, Heart, Liver & Kidney
- Also called
- 5-amino-1-methylquinolinium iodide, 5amino, 5A1MQ, 5AM1
- Last reviewed
- 2026-10-11
- Small-molecule (not a peptide) membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme in fat tissue that consumes NAD+ precursors; experimental research compound, no human trials, not FDA-approved.12
Not a peptide: a small-molecule inhibitor of the enzyme NNMT, often sold and discussed alongside peptides.
Regulatory status A March 2026 report on FDA warning letters says FDA inspectors found that compounder GenoGenix made 5-Amino-1MQ, which is ineligible for the section 503B compounding exemptions. 3
Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels.
Mouse study of methylquinolinium NNMT inhibitors, the compound class sold as 5-Amino-1MQ; no human data.
What is 5-Amino-1MQ researched for?
The three outcomes most discussed for 5-Amino-1MQ in the sources below, as those sources report them. humanpeptides.fyi makes no claims of its own: a listed benefit can be unproven or can have failed in trials, and the label on each line says which.
Fat loss, mice
- Fat loss: in diet-induced obese mice, 11 days of injections cut body weight ~5.1% (controls gained 1.4%), reduced white fat mass ~35% and adipocyte size, and lowered cholesterol ~30% without changing food intakeanimal1
What do researchers and users say about 5-Amino-1MQ?
Importantly, improved muSC activity translated not only to larger myofibers after injury but also to greater contractile function, with the peak torque of the TA increased by ~70% in NNMTi-treated mice compared to controls.
Injured leg muscle in 24-month-old mice; muSC means muscle stem cells and TA is the tibialis anterior muscle.
Once this stuff builds up in your system, it really does give you a good clean boost of daily energy without affecting your sleep.
Self-report from a user also taking the investigational drug retatrutide and other compounds; other commenters in the thread noticed no effect.
What side effects of 5-Amino-1MQ are reported?
- No observable adverse effects in mouse study; human efficacy, dose and long-term safety unknown12
- Mild stomach upset, headaches, fatigue and occasional nausea, mostly when starting.anecdotal (community guide)10
- Diarrhea reported with oral tablets by one user also taking retatrutide, so the cause is unclear.anecdotal9
- Compounded product quality: FDA cited a facility compounding 5-Amino-1MQ and NAD+ for unsanitary conditions, and three patients given its NAD+ product needed emergency care.FDA warning letter (reported by BioSpace)3
What do peptide guides say about 5-Amino-1MQ?
- PepEdHub PepEdHub describes 5-Amino-1MQ as a small-molecule NNMT inhibitor said to raise NAD+, activate SIRT1 and shrink fat cells, while acknowledging limited long-term human safety data. 11
- NCBI PMC In obese mice, an NNMT inhibitor cut body weight and white fat and lowered cholesterol without reducing food intake, and the researchers observed no adverse effects. 1
- NCBI PMC In elderly mice with muscle injury, NNMT inhibition revived muscle stem cells, producing nearly twice the regenerating fiber size and stronger contractions than untreated controls. 4
- Seek Peptides Seek Peptides notes genotoxicity tests in bacteria, cells and mice were negative, but stresses that human trials are lacking and long-term effects are unstudied even in animals. 10
What does the research say, system by system?
Body & tissues1
Hormones & physiology1
- Lowered total cholesterol ~30% in obese miceanimal1
Cells & mitochondria1
- NNMT inhibition preserves NAD+ salvage, supporting muscle stem-cell function and adipocyte metabolismanimal/in vitro4
Brain, mood & sleep1
- Some users report alertness/focus changesanecdotal7
Weight & metabolism1
- ~5% weight loss and 35% less fat mass in obese mice without appetite changeanimal1
Muscle1
- Improved regeneration and strength of aged injured muscleanimal4
Also notable1
- Commonly taken orally per community guides, at amounts extrapolated from animal work and not validated in humans (amounts omitted here)12
How strong is the evidence for 5-Amino-1MQ?
Animal studies only + anecdotal; no human trials
Mostly cell and animal studies. Human effects unknown. How tiers work
Questions about 5-Amino-1MQ
What is 5-Amino-1MQ?
Small-molecule (not a peptide) membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme in fat tissue that consumes NAD+ precursors. Not a peptide: a small-molecule inhibitor of the enzyme NNMT, often sold and discussed alongside peptides.
Is 5-Amino-1MQ FDA-approved?
A March 2026 report on FDA warning letters says FDA inspectors found that compounder GenoGenix made 5-Amino-1MQ, which is ineligible for the section 503B compounding exemptions.
What is 5-Amino-1MQ researched for?
The sources cited on this page most often discuss three outcomes: Fat loss, mice; Aged muscle regeneration, mice; Metabolic health, mice. Each line above shows what the source reports and how strong that evidence is.
What side effects of 5-Amino-1MQ are reported?
Reported in the cited sources: No observable adverse effects in mouse study; human efficacy, dose and long-term safety unknown; Mild stomach upset, headaches, fatigue and occasional nausea, mostly when starting; Diarrhea reported with oral tablets by one user also taking retatrutide, so the cause is unclear. The list is not complete, and few listed risks does not mean a compound is safe.
How strong is the evidence for 5-Amino-1MQ?
Evidence label: Preclinical. Animal studies only + anecdotal; no human trials.
What else is 5-Amino-1MQ called?
Names used for it include 5-amino-1-methylquinolinium iodide, 5amino, 5A1MQ, 5AM1.
Does humanpeptides.fyi recommend 5-Amino-1MQ?
No. humanpeptides.fyi makes no claims and no recommendations of its own. It summarizes and links to what others have published and posted. Nothing here is medical advice; talk to a licensed clinician.