---
title: "CJC-1295 without DAC: what sources report"
url: https://humanpeptides.fyi/peptides/cjc-1295-no-dac
site: humanpeptides.fyi
last_reviewed: 2026-10-11
---
# CJC-1295 without DAC
> humanpeptides.fyi makes no claims of its own. Every statement below reports what a cited source says, with its link. Not medical advice.
CJC-1295 without DAC: Modified GRF(1-29), a tetra-substituted GHRH analogue (D-Ala2, Gln8, Ala15, Leu27) with ~30 min half-life that produces short GH pulses rather than the multi-day elevation of the DAC version. The sources cited here most often discuss it for: Natural-pattern GH pulses, theoretical; Deeper sleep, anecdotal; Body composition, anecdotal. Evidence label: Preclinical.
## At a glance
- **Type:** Peptide
- **Family:** Growth Hormone Axis
- **Evidence label:** Preclinical (2 of 5)
- **Regulatory status:** FDA's compounding safety listing for CJC-1295 (form not specified) cited serious adverse events including increased heart rate and a systemic vasodilatory reaction, and the nomination was later withdrawn.
- **Goals discussed:** Hormones & Fertility, Sleep, Muscle & Tone, Fat Loss & Metabolism, Healing & Recovery
- **Also called:** Modified GRF (1-29), tetrasubstituted GRF (1-29), Mod GRF 1-29, CJC-1295 no DAC
- **Last reviewed:** 2026-10-11
## What is CJC-1295 without DAC?
- Modified GRF(1-29), a tetra-substituted GHRH analogue (D-Ala2, Gln8, Ala15, Leu27) with ~30 min half-life that produces short GH pulses rather than the multi-day elevation of the DAC version; not FDA-approved, WADA S2 prohibited. Sources: ,
Often sold simply as CJC-1295; the published CJC-1295 human trials used the DAC version, so their results do not carry over to Mod GRF 1-29.
**Regulatory status:** FDA's compounding safety listing for CJC-1295 (form not specified) cited serious adverse events including increased heart rate and a systemic vasodilatory reaction, and the nomination was later withdrawn. Source:
## What is CJC-1295 without DAC researched for?
### 1. Natural-pattern GH pulses, theoretical
- Short pulsatile GH release mimicking natural GHRH; used for GH/IGF-1 support (mechanistic; no dedicated human trial of the no-DAC form found - published human CJC data are for the DAC version) Sources: , ,
- Goals: [Hormones & Fertility](https://humanpeptides.fyi/objectives/hormones)
### 2. Deeper sleep, anecdotal
- Sleep: users commonly report deeper sleep (anecdotal); parent hormone GHRH increased slow-wave sleep in a 1999 human study (indirect) Sources: ,
- Goals: [Sleep](https://humanpeptides.fyi/objectives/sleep)
### 3. Body composition, anecdotal
- Body composition/recovery changes reported by users after ~8-12 weeks, usually stacked with ipamorelin (anecdotal/Reddit) Sources:
- Goals: [Muscle & Tone](https://humanpeptides.fyi/objectives/muscle), [Fat Loss & Metabolism](https://humanpeptides.fyi/objectives/fat-loss), [Healing & Recovery](https://humanpeptides.fyi/objectives/healing)
## What do researchers and users say about CJC-1295 without DAC?
> "FDA has identified serious adverse events associated with CJC-1295 including increased heart rate and systemic vasodilatory reaction."
>
> U.S. Food and Drug Administration, Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks.
Context: FDA's safety assessment of CJC-1295 as a nominated compounding substance; the entry does not say which form.
> "The days I don’t take it, I can’t sleep, days I do, I sleep like a rock."
>
> Anonymous user, r/BodyHackGuide, 3 months of CJC-1295 (No DAC) + Ipamorelin: My data on fixing chronic insomnia and body composition..
Context: User taking CJC-1295 without DAC combined with ipamorelin, describing sleep on and off days.
> "I find it damages my sleep. It pushes me too far into deep sleep, and the lack of REM means I wake up groggy and sluggish."
>
> Anonymous user, r/BodyHackGuide, 3 months of CJC-1295 (No DAC) + Ipamorelin: My data on fixing chronic insomnia and body composition..
Context: Reply in the same thread from a user with the opposite sleep experience on the CJC-1295 (no DAC) and ipamorelin combination.
## What side effects of CJC-1295 without DAC are reported?
- Flushing, injection-site reactions, headache, water retention reported for CJC-1295 generally Sources:
- Long-term safety of chronic GH elevation unknown; research-grade purity concerns Sources:
- Higher overnight heart rate, lower heart-rate variability and worse sleep, reported by one user taking it with ipamorelin (anecdotal) Sources:
- Waking wide awake in the night, or groggy REM-poor sleep, reported by some users who took it at night (anecdotal) Sources:
- A forearm compression sensation late in a cycle, reported by one long-term user (anecdotal) Sources:
- Serious adverse events including increased heart rate and a systemic vasodilatory reaction cited for CJC-1295, form not specified (FDA assessment) Sources:
## What do peptide guides say about CJC-1295 without DAC?
- **Dr. Axe:** Dr. Axe's guide lists the CJC-1295 and ipamorelin pairing as research-only with insufficient evidence, noting the cited human study evaluated CJC-1295 alone, and says WADA bans it.
- **PepEdHub:** PepEdHub notes the no-DAC form, Mod GRF 1-29, lasts about 30 minutes in the body and produces short GH pulses, versus 6 to 8 days for the DAC version.
- **Seek Peptides:** Seek Peptides lists Mod GRF 1-29 as a short-acting GH releaser that creates pulses, usually paired with GHRP-type peptides for muscle building and recovery.
## What does the research say, system by system?
### Hormones & physiology
- Acts on pituitary GHRH receptor to release GH (and downstream IGF-1) in brief pulses; 2005 rat study showed acute GH secretion from GRF(1-29) analogues (animal) Sources:
### Brain, mood & sleep
- Anecdotal deeper sleep; some users report disrupted sleep or a raised heart rate Sources:
### Weight & metabolism
- No controlled data; anecdotal fat loss reports Sources:
### Muscle
- No controlled data; theorized via GH/IGF-1 Sources:
### Also notable
- Requires multiple daily injections (often 2-3x/day or nightly) due to short half-life (community reports) Sources:
## How strong is the evidence for CJC-1295 without DAC?
**Preclinical** (2 of 5). Mechanistic/animal + anecdotal; no human trials of the no-DAC form
_Mostly cell and animal studies. Human effects unknown._
## Street names and stacks
- Appears in community stacks: [The Power Combo / Liquid Gold](https://humanpeptides.fyi/street-names#power-combo)
## Questions about CJC-1295 without DAC
### What is CJC-1295 without DAC?
Modified GRF(1-29), a tetra-substituted GHRH analogue (D-Ala2, Gln8, Ala15, Leu27) with ~30 min half-life that produces short GH pulses rather than the multi-day elevation of the DAC version. Often sold simply as CJC-1295; the published CJC-1295 human trials used the DAC version, so their results do not carry over to Mod GRF 1-29.
### Is CJC-1295 without DAC FDA-approved?
FDA's compounding safety listing for CJC-1295 (form not specified) cited serious adverse events including increased heart rate and a systemic vasodilatory reaction, and the nomination was later withdrawn.
### What is CJC-1295 without DAC researched for?
The sources cited on this page most often discuss three outcomes: Natural-pattern GH pulses, theoretical; Deeper sleep, anecdotal; Body composition, anecdotal. Each line above shows what the source reports and how strong that evidence is.
### What side effects of CJC-1295 without DAC are reported?
Reported in the cited sources: Flushing, injection-site reactions, headache, water retention reported for CJC-1295 generally; Long-term safety of chronic GH elevation unknown; research-grade purity concerns; Higher overnight heart rate, lower heart-rate variability and worse sleep, reported by one user taking it with ipamorelin. The list is not complete, and few listed risks does not mean a compound is safe.
### How strong is the evidence for CJC-1295 without DAC?
Evidence label: Preclinical. Mechanistic/animal + anecdotal; no human trials of the no-DAC form.
### What else is CJC-1295 without DAC called?
Names used for it include Modified GRF (1-29), tetrasubstituted GRF (1-29), Mod GRF 1-29, CJC-1295 no DAC.
### Does humanpeptides.fyi recommend CJC-1295 without DAC?
No. humanpeptides.fyi makes no claims and no recommendations of its own. It summarizes and links to what others have published and posted. Nothing here is medical advice; talk to a licensed clinician.
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