FOXO4-DRI
FOXO4-DRI (FOXO4 D-retro-inverso peptide)
What is FOXO4-DRI?
FOXO4-DRI: Synthetic D-retro-inverso peptide that disrupts FOXO4-p53 binding, pushing senescent cells into apoptosis (a senolytic). The sources cited here most often discuss it for: Clears senescent cells, mice; Chemo toxicity protection, mice; Kidney function, mice. Evidence label: Preclinical.
- Type
- Peptide
- Family
- Longevity & Mitochondria
- Evidence label
- Preclinical (2 of 5)
- Regulatory status
- Not FDA-approved for any indication and never tested in a registered human trial; in the US it is classified as unregulated and is available as a research chemical.
- Goals discussed
- Longevity & Cellular Aging, Hair, Energy & Endurance, Heart, Liver & Kidney
- Also called
- Proxofim, FOXO4-D-Retro-Inverso, FOXO4 DRI, FOXO4DRI, fox04
- Last reviewed
- 2026-10-11
- Synthetic D-retro-inverso peptide that disrupts FOXO4-p53 binding, pushing senescent cells into apoptosis (a senolytic); experimental, never tested in a registered human trial; not FDA-approved.12
Some products are labeled only as FOXO4, and users report uncertainty about whether these are FOXO4-DRI. Proxofim is a commercial name rather than a name used in the scientific literature.
Regulatory status Not FDA-approved for any indication and never tested in a registered human trial; in the US it is classified as unregulated and is available as a research chemical. 3
Thus, therapeutic targeting of senescent cells is feasible under conditions where loss of health has already occurred and in doing so tissue homeostasis can effectively be restored.
Conclusion of the mouse study that introduced FOXO4-DRI.
What is FOXO4-DRI researched for?
The three outcomes most discussed for FOXO4-DRI in the sources below, as those sources report them. humanpeptides.fyi makes no claims of its own: a listed benefit can be unproven or can have failed in trials, and the label on each line says which.
Chemo toxicity protection, mice
- Chemotoxicity protection: reduced doxorubicin-induced liver toxicity in miceanimal1
What do researchers and users say about FOXO4-DRI?
It is unclear as how many people are choosing to do that, and certainly we'll never see any sort of useful data resulting from that use.
Refers to people buying FOXO4-DRI from peptide sellers for personal use.
I had a dull headache for the first 3 days and felt a little sluggish for the first 5 days.
One user's self-report; the same user also noted weight loss and more frequent urination. Anecdotal.
What side effects of FOXO4-DRI are reported?
- No human trial data; users report injection-site burning, flu-like symptoms, fatigue, headaches; one unverified report of severe blood pressure rise; theoretical concerns re p53 tumor suppressionanecdotal/review28
- More frequent urination reported by a user during a course.anecdotal5
- Diarrhea and injection-site reactions are among reported effects.anecdotal3
- Senescent cells also help with wound healing and tissue repair, so clearing them could in theory interfere with those processes.theoretical3
- Whether repeated doses of this synthetic D-amino-acid peptide trigger immune reactions has not been studied.theoretical3
What do peptide guides say about FOXO4-DRI?
- PepEdHub PepEdHub explains that FOXO4-DRI stops FOXO4 from holding p53 inside senescent 'zombie cells', letting them self-destruct, and cautions that human safety data are limited. 9
- NCBI PMC In naturally aged mice, FOXO4-DRI cleared senescent testosterone-producing Leydig cells and eased the age-related drop in testosterone secretion. 10
- Fight Aging! Fight Aging! reports that Cleara Biotech was formed to commercialize the original FOXO4-DRI work but remains preclinical, focusing more on the FOXO4-p53 target than on the peptide itself. 7
- Peptide Protocol Wiki Peptide Protocol Wiki notes the key FOXO4-DRI findings come mainly from one research group, with limited independent replication and no human trials started or registered. 3
What does the research say, system by system?
Body & tissues1
- Kidney, liver, hair/fur in miceanimal1
Hormones & physiology1
- Targets p53-FOXO4 axis; reduced senescence markers (animal) )30246-5.pdf11
Cells & mitochondria1
- Induces apoptosis selectively in senescent cells, reducing senescent-cell burdenanimal/in vitro1
Brain, mood & sleep1
- Improved responsiveness and running activity in aged mice (animal) )30246-5.pdf11
Weight & metabolism1
- Occasional weight loss reported by usersanecdotal2
Muscle1
- Improved fitness/running in aged mice; no muscle-specific dataanimal1
How strong is the evidence for FOXO4-DRI?
Animal (one landmark mouse study) + anecdotal; no human trials
Mostly cell and animal studies. Human effects unknown. How tiers work
Questions about FOXO4-DRI
What is FOXO4-DRI?
Synthetic D-retro-inverso peptide that disrupts FOXO4-p53 binding, pushing senescent cells into apoptosis (a senolytic). Some products are labeled only as FOXO4, and users report uncertainty about whether these are FOXO4-DRI. Proxofim is a commercial name rather than a name used in the scientific literature.
Is FOXO4-DRI FDA-approved?
Not FDA-approved for any indication and never tested in a registered human trial; in the US it is classified as unregulated and is available as a research chemical.
What is FOXO4-DRI researched for?
The sources cited on this page most often discuss three outcomes: Clears senescent cells, mice; Chemo toxicity protection, mice; Kidney function, mice. Each line above shows what the source reports and how strong that evidence is.
What side effects of FOXO4-DRI are reported?
Reported in the cited sources: No human trial data; users report injection-site burning, flu-like symptoms, fatigue, headaches; one unverified report of severe blood pressure rise; theoretical concerns re p53 tumor suppression; More frequent urination reported by a user during a course; Diarrhea and injection-site reactions are among reported effects. The list is not complete, and few listed risks does not mean a compound is safe.
How strong is the evidence for FOXO4-DRI?
Evidence label: Preclinical. Animal (one landmark mouse study) + anecdotal; no human trials.
What else is FOXO4-DRI called?
Names used for it include Proxofim, FOXO4-D-Retro-Inverso, FOXO4 DRI, FOXO4DRI, fox04.
Does humanpeptides.fyi recommend FOXO4-DRI?
No. humanpeptides.fyi makes no claims and no recommendations of its own. It summarizes and links to what others have published and posted. Nothing here is medical advice; talk to a licensed clinician.